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The Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center presents
  • 15th Annual Mild Cognitive Impairment Symposium
  • Special Topic Workshop
  • Alzheimer's Public Educational Forum

January 14-15, 2017 | Miami Beach, Florida, USA

AGENDA

15th Annual Mild Cognitive Impairment (MCI) Symposium 

Biological and Clinical Aspects of Disorders Presenting as MCI

Saturday, JANUARY 14, 2017  ♦  7:30 am – 7:30 pm

7:15 am – 8:15Check-in and Continental Breakfast
8:15 – 8:30Welcome Notes/Introduction to SymposiumRanjan Duara, MD
Mount Sinai Medical Center, Miami Beach, FL
8:30-11:25SESSION 1: Seeding and Spread in Neurodegenerative Diseases
Chair: Todd Golde, MD, PhD
University of Florida, Gainesville, FL


Alzheimer’s disease is the most frequent pathology associated with cognitive impairment in older adults. Rare disorders such as Creutzfeldt–Jakob disease (CJD) are known to be seeded and propagated by infectious agents known as prions. Evidence is emerging that common neurodegenerative disorders such as AD may also involve seeding (by misfolded proteins) and subsequent spreading among vulnerable neuronal paths. The precise mechanisms are unclear.

This session will first explore the findings at the cellular level for seeding and propagation, including possible therapeutic targets. Clinical evidence from imaging studies for spreading of neurodegeneration in a stereotypical pattern and the clinical implications of this phenomenon will also be presented.
8:30 – 8:35Session OverviewTodd Golde, MD, PhD
University of Florida, Gainesville, FL
8:35 – 9:05KEYNOTE LECTURE: Mechanisms of Protein Seeding in Neurodegenerative Diseases
Lary Walker, PhD
Emory University, Atlanta, GA
9:05 – 9:10Q&A
9:10 – 9:25Prion-like Propagation of Alpha-synuclein Aggregates in the Brain of Wild-type MiceNolwen Rey, PhD,
Van Andel Institute, Grand Rapids, MI
9:25 – 9:30Q&A
9:30 – 9:45Prion-like Mechanisms of Disease Progression on Alzheimer’s Disease: New Therapeutic Opportunities David Borchelt, PhD
University of Florida, Gainesville, FL
9:45 – 9:50Q&A
9:50 – 10:15BREAK
10:15 – 10:30Network-Based Spread in AD: Evidence from Multi-Modal Human NeuroimagingGil Rabinovici, MD
University of California San Francisco, CA
10:30 – 10:35Q&A
10:35 – 10:50 Clinicopathologic Heterogeneity of Neurofibrillary Tangle PatternsMelissa Murray, PhD
Mayo Clinic, Jacksonville, FL
10:50 – 10:55Q&A
10:55-11:25Panel Discussion/Q&A
11:25 am – 3:15 pm
SESSION 2: Progression Rates in Preclinical and Prodromal Neurodegenerative Disorders
Chair: Ronald Petersen, MD, PhD
Mayo Clinic, Rochester, MN


Among patients with preclinical or prodromal AD and other neurodegenerative disease the mode of progression of the disease may be variable, resulting in variable pathological and clinical subtypes of the disease. Baseline measures using fluid biomarkers, imaging and sensitive neurocognitive assessments, can increase the accuracy of predicting future cognitive decline at an early stage of disease. This session will explore these variable pathological subtypes and will describe the utility of clinical symptoms, genetics, functional and structural MRI, amyloid PET and Tau PET in predicting clinical progression of early AD.
11:25 am – 11:30Session OverviewRonald Petersen, MD, PhD
Mayo Clinic, Rochester, MN
11:30 – 12:00 KEYNOTE LECTURE: Community Predictors of Progression in Preclinical and MCI Due to ADRonald Petersen, MD, PhD
Mayo Clinic, Rochester, MN
12:00 pm - 12:05 pmQ&A
12:05 – 12:20Cognitive Decline in Preclinical Alzheimer’s Disease

Beth Mormino, PhD
Massachusetts General Hospital, Boston, MA
12:20 –12:25Q&A
12:25 –12:40 Imaging Predictors of Progression (Amyloid and Tau PET) Adam Fleisher, MD
Eli Lilly & Co., Inc., Indianapolis, IN
12:40 – 12:45Q&A
12:45-1:45LUNCH
1:45 – 2:00CSF Predictors of Disease ProgressionAnne Fagan, PhD
Washington University in St Louis, MO
2:00 – 2:05Q&A
2:05 – 2:20Modeling Progression in Neurodegenerative Diseases Using Network ConnectivityAshish Raj, PhD
Weill Medical College of Cornell University, New York, NY
2:20 – 2:25Q&A
2:25 – 2:45Longitudinal Progression of Biomarkers and Clinical Symptoms in Dominantly Inherited ADEric McDade, DO, and Jason Hassenstab, PhD
Washington University in St Louis, MO
2:45 – 2:50Q&A
2:50 – 3:20Panel Discussion/ Q&A
3:20 – 3:45BREAK
3:45 – 6:15SESSION 3: Sleep Disorders and MCI
Chair: Steven DeKosky, MD
University of Florida, Gainesville, FL


Subjects with MCI and dementia are more likely to have sleep disorders than subjects with normal cognition. Specific patterns of sleep disorders are characteristic of some neurodegenerative diseases, such as Lewy Body Dementia and Parkinson Dementia. Sleep is important for consolidating memory and other cognitive function. During sleep there is a change in the cellular architecture of the brain, opening channels which allow toxic substances, including beta-amyloid to be removed from the brain.

Evidence for a causal relationship between poor sleep and future cognitive decline is provided by epidemiological, clinical and brain imaging studies. Some studies also suggest that sleep can be protective against AD.
3:45 – 3:50Session OverviewSteven DeKosky, MD
University of Florida, Gainesville, FL
3:50 – 4:05Sleep, Aging, and Brain Health: Implications for PreventionAdam Spira, PhD
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
4:05 – 4:10Q&A
4:10 – 4:25Poor Sleep before Dementia: A Risk Factor for Cognitive Decline and Clinical Conversion?Bryce Mander, PhD
University of California, Berkeley, CA
4:25 – 4:30Q&A
4:30 – 5:00KEYNOTE LECTURE: The Glymphatic System, Sleep and NeurodegenerationJeffrey Iliff, PhD
OHSU, Portland, OR
5:00 – 5:05Q&A
5:05 – 5:20Obstructive Sleep Apnea, MCI and AD: Is there a Direct Link?Ricardo Osorio, MD
New York University Center on Brain Health, NY, NY
5:20 – 5:25Q&A
5:25 – 5:40REM Sleep Behavior Disorder and Neurodegenerative DiseaseMichael Howell, MD
University of Minnesota, Minneapolis, MN
5:40 – 5:45Q&A
5:45 – 6:15Panel Discussion/ Q&A
6:15 – 8:00Networking Reception

Special Topic Workshop: 

Assessment of Neuropsychological Test Performance in Cross Cultural Studies

Sunday, JANUARY 15, 2017  ♦  8:00 am – 1:30 pm                                  

7:30 am – 8:30Continental Breakfast and Check-in
8:30 – 12:30WORKSHOP:
Assessment of Neuropsychological Test Performance in Cross Cultural Studies
CHAIR: Monica Rosselli, PhD
Florida Atlantic University


This workshop will present genetic, clinical and neuroimaging findings conducted in Colombia on the largest known cohort of carriers of a rare autosomal dominant mutation with early age of onset. Furthermore, the prevalence of MCI and AD in Latin America will be analyzed. Additional presentations will explore the clinical validity of of neuropsychological tests for Spanish and English speakers living in the US who are diagnosed with MCI and early AD. Cultural and demographic variables in the diagnosis of abnormal aging will be discussed. The use of neuroimaging to better understand the relationship of structural brain changes to performance on neuropsychological tests among Spanish and English speakers will also be presented.
8:30 – 8:35Welcome NotesRanjan Duara, MD,
Mount Sinai Medical Center, Miami Beach, FL
8:35 – 8:40IntroductionMonica Rosselli, PhD
Florida Atlantic University, Davie, FL
8:40 – 9:05KEYNOTE LECTURE: The E280A PS1 Paisa Mutation and BiomarkersFrancisco Lopera, MD
Universidad de Antioquia, Medellín, Colombia
9:05 – 9:10Q&A
9:10 – 9:25Brain imaging and Biomarker Abnormalities in Cognitively-unimpaired Individuals with Autosomal-dominant Alzheimer's DiseaseYakeel Quiroz, PhD
Massachusetts General Hospital, Boston, MA
9:25 – 9:30Q&A
9:30 – 9:45The Development of Novel Cognitive Stress Paradigms for Detection of Early Cognitive Impairment in Cross-Cultural ResearchDavid Loewenstein, PhD
University of Miami, Miami, FL
9:45 – 9:50Q&A
9:50 – 10:05Neuropsychological Test Performance in Spanish and English Speakers with Normal Cognition and MCI Rosie Curiel, PsyD
University of Miami, Miami, FL
10:05 – 10:10Q&A
10:10 – 10:40BREAK
10:40 – 10:55Culture, Bilingualism, Neuropsychological Tests, and Biomarkers in MCI and early ADMonica Rosselli, PhD
Florida Atlantic University, Davie, FL
10:55 – 11:00Q&A
11:00 – 11:15Education and Late-life Cognitive Health in Diverse PopulationsDan Mungas, PhD
University of California, Davis, CA
11:15 – 11:20Q&A
11:20 – 11:35MCI in Latin American CountriesRicardo Nitrini , MD, PhD
FMUSP, São Paulo SP, Brazil
11:35 – 11:40Q&A
11:40 am – 12:00 pmConcluding RemarksVladimir Hachinski, MD, DSc
University of Western Ontario, London, ON
12:00 – 12:30 Panel Discussion/Q&A
Moderator: Oscar Lopez, MD
University of Pittsburgh, Pittsburgh, PA
12:30 – 1:30LUNCH

Alzheimer’s Public Educational Forum: 

New Concepts in Alzheimer’s Cause, Progression and Therapy

Sunday, JANUARY 15, 2017  ♦  1:00 pm – 5:00 pm                                

1:00 - 1:30pmCheck-in and Refreshments
1:30 – 5:00 EDUCATIONAL FORUM:
New Concepts in Alzheimer’s Cause, Progression and Therapy
Chair: David Loewenstein, PhD
University of Miami, Miami, FL


This event is intended for the public at large, including individuals at-risk for AD, their family members, as well as professionals from various fields who may be interested in an up-to-date review of some aspects of AD research. The forum will allow the audience to interact with top scientists in the field in the presence of a moderator. This educational segment aims to provide information about the latest research in the field of AD, including an on-going prevention trial, several epidemiological studies of aging, and investigations showing the effect of sleep on memory and mental health.
1:30 – 1:40Welcome NotesRanjan Duara, MD
Mount Sinai Medical Center, Miami Beach, FL
1:40 – 2:10KEYNOTE LECTURE:
Research to Clinic: Alzheimer's Disease Participation in Clinical Trials
Maria Carrillo, PhD
Alzheimer’s Association, Chicago, IL
2:10 – 2:15IntroductionDavid Loewenstein, PhD
University of Miami, Miami, FL
2:15 – 2:30Basis of Therapeutic Trials in Alzheimer’s Disease Reisa Sperling, MD
Massachusetts General Hospital, Boston, MA
2:30 – 2:35Q&A
2:35 – 2:50Declining Incidence of Alzheimer’s Disease – Is it Real? Mary Ganguli, MD, MPH
University of Pittsburgh, Pittsburgh, PA
2:50 – 2:55Q&A
2:55 – 3:10How Do Neurodegenerative Diseases Progress?Lary Walker, PhD
Emory University, Atlanta, GA
3:10 – 3:15Q&A
3:15 – 3:45BREAK
3:45 – 4:00The Glymphatic System and the BrainJeffrey Iliff, PhD
OHSU, Portland, OR
4:00 – 4:05Q&A
4:05 – 4:20Why Sleep Should Not Be Ignored in Alzheimer's DiseaseBryce Mander, PhD
University of California, Berkeley, CA
4:20 – 4:25Q&A
4:25 – 4:55Panel Discussion and Q&A
4:55 – 5:00Closing NotesRanjan Duara, MD
Mount Sinai Medical Center, Miami Beach, FL

Addressing Grievances about the MCI Symposium, the Special Topic Workshop or the Public Education Forum

Written evaluations are summarized and communicated to the activity’s Program Director and the faculty of the activity. Grievances shared directly at the conference are handled by the program staff or, if the grievance involves content, by the Program Director. Issues raised are shared with the faculty of the activity and considered when planning future activities.